As I was designing this solve, I kept being reminded of all the concepts I've learned from past puzzles.  I feel enormously grateful to all the puzzle designers who have created challenges to make me think, and all the solvers who have demonstrated and taught to me the solution principles I lean on today.  You all are a wonderful community and I appreciate you deeply.

*****

As for the solve itself.  I actually felt that the solution space for layouts was not very large.  With 2 inputs, 2 outputs, a projector, and debonder all requiring access, simple process of elimination meant that zero-access bonder and calcifier were necessary.  Add in the principles of "handedness" (projector and debonder must slant away from one another to ensure that the relevant fragments are adjacent) and suppression, and I only found 4 glyph configurations that met all criteria.  Two of them worked, and this one was smaller.

There is almost certainly Pentapig magic involving pocket dimensions that makes everything fit in 25 area.  But that's OK, because this is the best GA solve I've ever made.  Hats off to everyone who bests it!